Thursday, 16 August 2007

Three markers may predict type 2

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Here's more diabetes research gleaned from the long-term Women's Health Initiative Observational Study (WHIOS). 82,000 postmenopausal women from varying ethnicities are part of WHIOS, which examines the influence of behavior, socio-economic status, diet and other factors on a woman's health.

University of California, Los Angeles researchers identified thee markers that could predict type 2 diabetes before development of the disease. The molecules are inflammatory cytokines (messenger molecules) -- tumour necrosis factor-alpha (TNF-a); interleukin-6 (IL-6); and high-sensitivity C-reactive protein (hs-CRP). Across all four ethnic groups, hs-CRP was the most consistent predictor for increased risk of type 2. Interestingly, associations with these cytokines were independent of obesity or elevated levels of glucose and insulin.

Lead researcher Dr. Simin Liu stated the study was a final confirmation of earlier research on the underlying biology of type 2. He also said the pro-inflammatory state is often linked to obesity which can lead to insulin resistance. A simple blood test to identify these markers before the disease begins could encourage prevention of type 2 diabetes through nutrition and exercise. Motivation is one tough nut to crack, but I wish I'd be reading more research on cracking the nut for a cure. The study was published in the August 15 issue of Archives of Internal Medicine.

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