Tuesday, 14 August 2007

Preoperative therapy in patients with esophageal cancer shows survival benefit

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Researchers now report that surgery plus either preoperative chemotherapy or chemoradiotherapy for locally advanced esophageal squamous cell carcinoma (SCC) and adenocarcinoma does show a survival benefit.

Preoperative chemoradiotherapy resulted in a 19% reduction in mortality risk, with a greater survival benefit in patients with adenocarcinoma rather than SCC. Preoperative chemotherapy resulted in a 10% reduction in mortality risk, with this benefit seen only in patients with adenocarcinoma. These results come from a large meta-analysis of randomized trials.

Previous studies had shown that preoperative chemotherapy or radiotherapy did not show a survival benefit. However, many of these studies were small.

This study was published in Lancet Oncology in March 2007.

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